Semaglutide is now the most-searched prescription weight-loss treatment in the country, and dozens of online providers will sell it to you. They are not the same. Prices swing from under $100 to more than $1,500 a month, the medical care ranges from thorough to a rubber stamp, and the legal ground under the cheapest compounded options is shifting fast. We tracked the major providers and ranked them so you can choose with your eyes open.
The quick answer
If you want the most durable, lowest-risk choice, use a provider that prescribes brand-name semaglutide (Wegovy or Ozempic) or works with a licensed clinician who can. Ro is our overall pick for that reason. If price is the deciding factor, Hims & Hers is the best value among the large, established companies. Read the ranking method at the end so you know exactly how we scored these.
| # | Provider | Best for | Rating | Starting price* | Type |
|---|---|---|---|---|---|
| 1 | Ro | Best overall | From $99/mo program fee | Brand-name | |
| 2 | Hims & Hers | Best value | From $79/mo | Brand-name | |
| 3 | Noom Med | Best coaching | From $149/mo | Brand-name | |
| 4 | TrimRX | Flat-price compounded | From $179/mo | Compounded | |
| 5 | Henry Meds | Simple compounded plans | From $297/mo | Compounded |
*Starting prices are the providers’ advertised figures and change often. Confirm current pricing on each provider’s site before you buy.
1. Ro — Best overall
Ro is one of the largest and best-funded telehealth companies in the United States, and it shows in the weight-loss program. You are matched with a licensed clinician, the intake is thorough, and Ro can prescribe brand-name GLP-1 medication where appropriate rather than leaning only on compounded supply. That matters right now, because the compounded market is under active federal pressure. Ro is the choice that is least likely to be disrupted.
✓ Pros
- Prescribes brand-name GLP-1
- Established, well-funded, long track record
- Thorough medical intake
- Clear, upfront pricing
✕ Cons
- Not the cheapest option
- Brand-name medication cost depends on insurance
2. Hims & Hers — Best value
Hims & Hers is a public company with a large, polished telehealth operation. Its weight-loss program is one of the easiest to start and one of the more affordable among the established players, with both brand-name and compounded routes depending on your situation. If you want a recognizable, accountable company at a lower entry price, this is the one.
✓ Pros
- Large public company, accountable
- Lower entry price than most
- Fast, well-designed online intake
- Offers both brand and compounded paths
✕ Cons
- Compounded route carries the usual regulatory risk
- Upsells across other product lines
3. Noom Med — Best for coaching
Noom built its name on behavior-change coaching, and Noom Med pairs GLP-1 medication with that habit-and-psychology approach. If you believe the medication is only half the job and you want structured support to keep the weight off, Noom is the strongest fit. It costs more than a bare prescription, and that is the point.
Read our full Noom Med review →
4. TrimRX — Flat-price compounded
TrimRX is one of the better-run compounded providers. It leans hard into fighting counterfeit and unsafe online medication, its pricing is simple and flat, and the intake funnel is fast. The caveat applies to every compounded provider, not just this one: compounded semaglutide sits on contested legal ground and the supply could be disrupted. Read the disclaimer below before choosing any compounded option.
Before you pick a compounded provider, understand the risk. The FDA declared the semaglutide and tirzepatide shortages over in 2025, which ended the window that made mass compounding legal. In 2026 the FDA has issued warning letters to telehealth companies and proposed removing these drugs from the list compounders can use, and the drug makers are suing. Compounded programs are cheaper, but the supply and the legality can change quickly. Brand-name providers do not carry that specific risk.
How we ranked these programs
We do not take payment from providers to rank them, and an affiliate commission never moves a provider up the list. Every program is scored on the same five factors:
- True cost — the real monthly price including consultation and medication, not just the teaser rate.
- Quality of medical care — how thorough the clinician review is and whether real follow-up is available.
- Transparency — clear pricing, clear cancellation, no hidden auto-renewals.
- Medication handling — sourcing, pharmacy accreditation, and cold-chain shipping.
- Patient experience — verified reviews and reported outcomes.
Read the full ranking method →
Frequently asked questions
Is compounded semaglutide legal in 2026?
It is contested. The FDA declared the semaglutide and tirzepatide shortages over in 2025, which ended the window that allowed large-scale compounding. In 2026 the FDA has issued warning letters and proposed removing these drugs from the compounding list, and the manufacturers are suing. Patient-specific compounding with a documented medical need can still be legal, but the broad low-price compounded market is under active pressure.<br />
What is the cheapest legitimate way to get semaglutide online?
The lowest advertised prices come from compounded providers, often between $150 and $300 a month, but those carry the regulatory risk above. Among brand-name-capable providers, Hims advertises the lowest entry price. If you have insurance, a provider that prescribes brand-name Wegovy may end up cheaper than paying cash for compounded.<br />
Do I need insurance to use these programs?
No. Every provider on this page offers a cash-pay option with no insurance required. If you do have insurance, a brand-name-first provider like Ro can help check whether your plan covers the medication.<br />
How much weight can you lose on GLP-1 medication?
Clinical trials of brand-name GLP-1 drugs have shown average weight loss in the range of roughly 15 to 22 percent of body weight over about a year when combined with diet and lifestyle changes. Individual results vary widely and depend on the medication, dose, and adherence.<br />
Is semaglutide the same as Ozempic and Wegovy?
Semaglutide is the active ingredient in the brand-name drugs Ozempic and Wegovy. Compounded semaglutide is the same active ingredient prepared by a pharmacy rather than the FDA-approved branded product.